BENZA BLOCK S PREMIUM JO
ベンザブロックSプレミアム錠

• Isopropamide iodide and d-chlorpheniramine maleate relieve runny nose, stuffy nose, and sneezing.
• Tranexamic acid improves inflammation of the mucosa and relieves sore throat.
• Guaifenesin promotes the excretion of sputum.
• This medicine contains riboflavin (vitamin B₂) and hesperidin, a type of vitamin P.
• Ten ingredients are contained and relieve various symptoms of a cold.

Relief of various symptoms of a cold: runny nose, stuffy nose, sore throat, sneezing, cough, phlegm, feeling cold (chills due to fever), fever, headache, joint pain, and muscle pain.

Take the following amount of medicine without chewing with cold or lukewarm water within 30 minutes after a meal.

Precautions regarding dosage and directions

1. Children are permitted to take this medicine only under the direction and supervision of a parent or other responsible adult.
2. Please follow the recommended dosage and directions.

In 9 tablets (daily dose for persons aged 15 years or over)

Inactive ingredients:

Cellulose, carmellose calcium, hydroxypropyl cellulose, magnesium stearate, corn starch, hypromellose, copolyvidone, talc, titanium oxide, macrogol, red ferric oxide

Precautions regarding ingredients

Although urine may turn yellow after taking this medicine, do not worry because this is caused by riboflavin in this medicine.

What you should NOT do

(If you do not follow the precautions listed below, your current symptoms may worsen and you may be at an increased risk of side effects and accidents.)

1. The following persons should not take this medicine:
   1. Persons who have had allergies to this medicine or ingredients of this medicine
   2. Persons who have had asthma after taking this medicine or other cold medications or antipyretic analgesics
   3. Children under 12 years
2. Do not use any of the following medicines while you take this medicine:
   Other cold medicines, antipyretic analgesics, sedating drugs, cough and expectorant drugs, oral remedies containing an antihistamine agent (such as oral remedies for rhinitis, motion sickness drugs, medicines for allergies, and sedative hypnotics), etc., gastrointestinal analgesics and antispasmodics, oral remedies containing tranexamic acid
3. Do not operate vehicles or machines after taking this medicine.
   (Symptoms such as sleepiness, blurred vision, and abnormal brightness may appear.)
4. Do not take this medicine if breastfeeding. Stop breastfeeding if taking this medicine.
5. Do not drink alcohol before or after taking this medicine.
6. Do not take this medicine regularly for long periods.

Who should seek consultation

1. The following persons should consult a physician, pharmacist or registered salesperson* before taking this medicine:
   1. Persons under treatment by a physician or dentist
   2. Women who are or may be pregnant
   3. Elderly persons
   4. Persons who have had allergies to medicines or something
   5. Persons who have suffered from the following symptoms: High fever, dysuria
   6. Persons diagnosed with the following conditions: Thyroid dysfunction, diabetes, heart disease, hypertension, liver disease, kidney disease, gastric and duodenal ulcer, glaucoma, persons with blood clots (cerebral thrombosis, cardiac infarction, thrombophlebitis), persons at risk of developing thrombosis, respiratory malfunction, obstructive sleep apnea syndrome, obesity
   7. Persons taking oral medicines containing parasympatholytic agents (such as belladonna total alkaloid, isopropamide iodide, and scopolia extract)
2. Stop taking this medicine immediately and consult a physician, pharmacist, or registered salesperson if the following symptoms appear after taking this medicine because they might be side effects of the medicine. Take this leaflet with you.

   Affected area	Symptoms
   Skin	Rashes, redness, itching
   Digestive organs	Nausea, vomiting, loss of appetite, heartburn
   Neuropsychiatric system	Dizziness, headache
   Urinary organs	Dysuria
   Others	Excess body temperature decrease, hot flushes of the face, abnormal brightness

   In rare cases, serious symptoms might occur. In such a case, immediately consult a physician.

   Names of symptoms	Symptoms
   Shock (Anaphylaxis)	Symptoms such as itching of the skin, urticaria, hoarseness, sneezing, itching of the throat, breathing difficulties, palpitations, and clouded consciousness will appear immediately after taking the medicine.
   Mucocutaneous ocular syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis, acute generalized exanthematous pustulosis	Symptoms such as high fever, hyperemia of the eyes, eye discharge, ulceration of the lips, sore throat, rashes and redness of a large area of the skin, small rashes (small pustules) on reddened skin, heaviness of the whole body, and no appetite persist or suddenly worsen.
   Hepatic function disorder	Symptoms such as fever, itching, rashes, jaundice (yellowing of the skin and white part of the eye), brown urine, heaviness of the whole body, and loss of appetite will appear.
   Renal disorder	Symptoms such as fever, rashes, reduced urine output, swelling of the whole body, heaviness of the whole body, joint pain (feeling pain in the joints), and diarrhea will appear.
   Interstitial pneumonia	When you go upstairs or exert yourself too much, symptoms such as shortness of breath, breathing difficulties, dry cough, and fever will appear. They will appear suddenly and persist.
   Asthma	Symptoms such as wheezing during breathing and breathing difficulties will appear.
   Hypoplastic anemia	Symptoms such as bruising, nose bleeding, bleeding gums, fever, pale skin or membranes, feeling of fatigue, palpitations, shortness of breath, feeling ill, dizziness, and blood in urine will appear.
   Agranulocytosis	Symptoms such as sudden high fever, chills, and sore throat will appear.
   Respiratory depression	Shortness of breath, breathing difficulties, etc., will appear.

3. Stop taking this medicine and consult a physician, pharmacist, or registered salesperson if the following symptoms appear after taking this medicine and continue or worsen. Take this leaflet with you.
   Constipation, dry mouth, sleepiness, blurred vision, diarrhea
4. Stop taking this medicine and consult a physician, pharmacist, or registered salesperson if symptoms do not improve after taking this medicine five to six times. Take this leaflet with you.

*Registered salesperson: person who has the license to sell OTC medicines except Category 1.

1. Keep the bottle tightly closed and store it in a dry, cool place away from direct sunlight.
2. Keep out of the reach of children.
3. To prevent improper use or loss of quality, do not transfer the medicine to another container.
4. Once the bottle is opened, throw away the filler in the bottle. (Putting the filler back into the bottle may change the quality by absorbing moisture. The filler in the bottle protects the tablets from breakage during transportation.)
5. Be sure to close the cap tightly after each use. (Failure to tightly close the bottle may result in loss of the quality of the medicine due to moisture.)
6. Do not take this medicine after the expiration date.
7. Fill in the date when the bottle was opened in the column provided on the box and bottle.
8. Once the bottle is opened, take this medicine within about 6 months to maintain quality.